Chemical Name: 1,4-Dihydrophenonthrolin-4-one-3-carboxylic acid
Prolyl hydroxylase inhibitor
Molekulargewicht:
240.22
Reinheit:
98% by HPLC, NMR (Conforms)
Formulierung:
Off-white solid
CAS Nummer:
[331830-20-7]
Formel:
C13H8N2O3
Anwendungsbeschreibung:
Potent inhibitor of prolyl 4-hydroxylase (IC50=2-4 µM)1. Inhibits collagen deposition via inhibition of collagen proline hydroxylation2,3. Subcutaneous injection of a 1,4-DPCA containing hydrogel into Swiss Webster mice that do not show a regenerative phenotype increased expression of HIF1alpha over 5 days. Multiple injections led to regenerative wound healing after ear hole punch injury4.
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