Potent inhibitor of prolyl 4-hydroxylase (IC50=2-4 µM)1. Inhibits collagen deposition via inhibition of collagen proline hydroxylation2,3. Subcutaneous injection of a 1,4-DPCA containing hydrogel into Swiss Webster mice that do not show a regenerative phenotype increased expression of HIF1alpha over 5 days. Multiple injections led to regenerative wound healing after ear hole punch injury4.
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