Chemical Name: N-[(4-Acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide
SIRT1 and 2 inhibitor
Molekulargewicht:
369.48
Reinheit:
>98% by HPLC NMR (Conforms)
Formulierung:
White solid
CAS Nummer:
[380315-80-0]
Formel:
C20H23N3O2S
Anwendungsbeschreibung:
Tenovin-1 activates p53 via inhibition of SIRT1 and SIRT2.1,2 Induces apoptosis in a variety of cancer cell lines including cutaneous T-cell lymphoma3 and melanoma4 among others5. Induces cellular senescence in cultured rat primary astrocytes6 as well as other cell types.
10-2982
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