SB-525334, CAS [[356559-20-1]]

Produktübersicht

• Artikelname: SB-525334, CAS [[356559-20-1]]
• Artikelnummer: FBM-10-2983
• Hersteller Artikelnummer: 10-2983
• Alternativnummer: FBM-10-2983-5MG, FBM-10-2983-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline

Produktbeschreibung

ALK5 (TGFbetaR1) inhibitor

Produkteigenschaften

• Molekulargewicht: 343.42
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: Yellow solid
• CAS Nummer: [356559-20-1]
• Formel: C21H21N5

Anwendungsbeschreibung

• Anwendungsbeschreibung: Potent and selective inhibitor of the transforming growth factor beta 1 receptor, activin receptor-like kinase (ALK5), IC50 = 14.3 nM and ALK4 (IC50 = 58.5 nM) with no activity at ALK2, 3 and 61. Blocks fibrosis markers and renal injury in the puromycin-induced nephritis model1. It causes significant attenuation in Smad2/3 nuclear translocation, decrease in CTGF-expressing cells, myofibroblast proliferation and type 1 collagen deposition resulting in an overall attenuation in bleomycin-induced pulmonary fibrosis2. Sensitizes drug-resistant pancreatic cancer cells to gemcitabine3. Cell permeable and active in vivo.