SB-525334, CAS [[356559-20-1]]

Product Overview

• Article Name: SB-525334, CAS [[356559-20-1]]
• Biozol Catalog Number: FBM-10-2983
• Supplier Catalog Number: 10-2983
• Alternative Catalog Number: FBM-10-2983-5MG, FBM-10-2983-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline

Product Description

ALK5 (TGFbetaR1) inhibitor

Product Properties

• Molecular Weight: 343.42
• Purity: 98% by HPLC NMR (Conforms)
• Form: Yellow solid
• CAS Number: [356559-20-1]
• Formula: C21H21N5

Application Notes

• Application Notes: Potent and selective inhibitor of the transforming growth factor beta 1 receptor, activin receptor-like kinase (ALK5), IC50 = 14.3 nM and ALK4 (IC50 = 58.5 nM) with no activity at ALK2, 3 and 61. Blocks fibrosis markers and renal injury in the puromycin-induced nephritis model1. It causes significant attenuation in Smad2/3 nuclear translocation, decrease in CTGF-expressing cells, myofibroblast proliferation and type 1 collagen deposition resulting in an overall attenuation in bleomycin-induced pulmonary fibrosis2. Sensitizes drug-resistant pancreatic cancer cells to gemcitabine3. Cell permeable and active in vivo.