MDL-28170, CAS [[88191-84-8]]

Produktübersicht

• Artikelname: MDL-28170, CAS [[88191-84-8]]
• Artikelnummer: FBM-10-3005
• Hersteller Artikelnummer: 10-3005
• Alternativnummer: FBM-10-3005-5MG, FBM-10-3005-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: N-Benzyloxycarbonylvalylphenylalaninal. Alternate Names: Z-Val-Phe-CHO, Calpain Inhibitor III

Produktbeschreibung

Calpain inhibitor

Produkteigenschaften

• Molekulargewicht: 382.45
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [88191-84-8]
• Formel: C22H26N2O4

Anwendungsbeschreibung

• Anwendungsbeschreibung: A potent and selective cell permeable calpain inhibitor. Inhibits oxidative damage-induced apoptosis in PC12 cells and capsaicin-induced apoptosis in dorsal root ganglion neurons.1 It penetrates the blood-brain barrier and inhibits brain cysteine protease activity after systemic administration, ameliorating brain damage in a gerbil model of global ischemia.2 Displays neuroprotective effects in neurotrama rodent models.3 Calpain I Ki = 8 nM, Cathepsin B Ki = 24 nM in isolated enzyme assays. IC50 = 0.3 µM in intact cell assay.4