Chemical Name: N-Benzyloxycarbonylvalylphenylalaninal. Alternate Names: Z-Val-Phe-CHO, Calpain Inhibitor III
Calpain inhibitor
Molecular Weight:
382.45
Purity:
98% by HPLC NMR (Conforms)
Form:
White solid
CAS Number:
[88191-84-8]
Formula:
C22H26N2O4
Application Notes:
A potent and selective cell permeable calpain inhibitor. Inhibits oxidative damage-induced apoptosis in PC12 cells and capsaicin-induced apoptosis in dorsal root ganglion neurons.1 It penetrates the blood-brain barrier and inhibits brain cysteine protease activity after systemic administration, ameliorating brain damage in a gerbil model of global ischemia.2 Displays neuroprotective effects in neurotrama rodent models.3 Calpain I Ki = 8 nM, Cathepsin B Ki = 24 nM in isolated enzyme assays. IC50 = 0.3 µM in intact cell assay.4
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