Homoharringtonine, CAS [[26833-87-4]]

Produktübersicht

• Artikelname: Homoharringtonine, CAS [[26833-87-4]]
• Artikelnummer: FBM-10-3033
• Hersteller Artikelnummer: 10-3033
• Alternativnummer: FBM-10-3033-5MG,FBM-10-3033-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: HHT, NSC141633, Omacetaxine mepesuccinate

Produktbeschreibung

Protein synthesis inhibitor

Produkteigenschaften

• Molekulargewicht: 545.63
• Reinheit: 95% by HPLC NMR (Conforms)
• Formulierung: Pale yellow to off-white solid
• CAS Nummer: [26833-87-4]
• Formel: C29H39NO9

Anwendungsbeschreibung

• Anwendungsbeschreibung: A plant alkaloid, originally isolated from the Hainan plum yew, that binds to the large ribosomal subunit A-site, competing with aminoacyl-tRNA amino acid side chains, thereby inhibiting the initial elongation step of protein synthesis.1 It also binds to transcription factors NKRF (NF-kappaB repressing factor) and SP1, down-regulating the Myc pathway.2,3 Dramatically decreases global DNA 5-hydroxymethylcytosine levels via the SP1/TET1 axis.3 Induces apoptosis in tyrosine kinase inhibitor-resistant NSCLC cells4, and is a clinically useful agent for CML and AML5.