A plant alkaloid, originally isolated from the Hainan plum yew, that binds to the large ribosomal subunit A-site, competing with aminoacyl-tRNA amino acid side chains, thereby inhibiting the initial elongation step of protein synthesis.1 It also binds to transcription factors NKRF (NF-kappaB repressing factor) and SP1, down-regulating the Myc pathway.2,3 Dramatically decreases global DNA 5-hydroxymethylcytosine levels via the SP1/TET1 axis.3 Induces apoptosis in tyrosine kinase inhibitor-resistant NSCLC cells4, and is a clinically useful agent for CML and AML5.
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