Compound 401, CAS [[168425-64-7]]

Produktübersicht

• Artikelname: Compound 401, CAS [[168425-64-7]]
• Artikelnummer: FBM-10-3055
• Hersteller Artikelnummer: 10-3055
• Alternativnummer: FBM-10-3055-5MG, FBM-10-3055-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 2-(4-Morpholinyl)-4H-pyrimido[2,1-a]isoquinolin-4-one

Produktbeschreibung

Dual DNA-PK/mTOR inhibitor

Produkteigenschaften

• Molekulargewicht: 381.32
• Reinheit: >98% by TLC/HPLC (NMR Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [168425-64-7]
• Formel: C16H15N3O2

Anwendungsbeschreibung

• Anwendungsbeschreibung: Compound 401 is a dual inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR), IC50s = 0.28 and 5.3 µM, respectively) with selectivity over PI3K, ATM, and ATR.1 Treatment of cells with 401 (10 µM) blocked the phosphorylation of sites modified by mTOR-Raptor and mTOR-Rictor complexes (ribosomal protein S6 kinase 1 Thr(389) and Akt Ser(473), respectively) with no direct inhibition of Akt Thr(308) phosphorylation, which is dependent on PI3K.2