Compound 401, CAS [[168425-64-7]]

Product Overview

• Article Name: Compound 401, CAS [[168425-64-7]]
• Biozol Catalog Number: FBM-10-3055
• Supplier Catalog Number: 10-3055
• Alternative Catalog Number: FBM-10-3055-5MG,FBM-10-3055-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien

Product Description

Dual DNA-PK/mTOR inhibitor

Product Properties

• Molecular Weight: 381.32
• Purity: >98% by TLC/HPLC (NMR Conforms)
• Form: Off-white solid
• CAS Number: [168425-64-7]
• Formula: C16H15N3O2

Application Notes

• Application Notes: Compound 401 is a dual inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR), IC50s = 0.28 and 5.3 µM, respectively) with selectivity over PI3K, ATM, and ATR.1 Treatment of cells with 401 (10 µM) blocked the phosphorylation of sites modified by mTOR-Raptor and mTOR-Rictor complexes (ribosomal protein S6 kinase 1 Thr(389) and Akt Ser(473), respectively) with no direct inhibition of Akt Thr(308) phosphorylation, which is dependent on PI3K.2