Tolcapone, CAS [[134308-13-7]]

Produktübersicht

• Artikelname: Tolcapone, CAS [[134308-13-7]]
• Artikelnummer: FBM-10-3075
• Hersteller Artikelnummer: 10-3075
• Alternativnummer: FBM-10-3075-10MG, FBM-10-3075-50MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: (3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone. Alternate Names: Ro 40-7592

Produktbeschreibung

COMT inhibitor, TTR aggregation inhibitor

Produkteigenschaften

• Molekulargewicht: 273.24
• Reinheit: 98% by TLC, NMR (Conforms)
• Formulierung: Yellow solid
• CAS Nummer: [134308-13-7]
• Formel: C14H11NO5

Anwendungsbeschreibung

• Anwendungsbeschreibung: Catechol O-methyltransferase inhibitor (COMT), inhibiting both brain and peripheral enzymes.1 Potent inhibitor of alpha-synuclein and beta-amyloid oligomerization and fibrillogenesis protecting against extracellular toxicity.2 Binds to transthyretin (TTR) with high affinity (21 to 58 nM) and inhibits TTR aggregation in human plasma and prevents TTR-induced cytotoxicity in vitro. Stabilizes TTR in mice and humans in vivo.3 Inhibits O-methylation of exogenous polyphenols such as EGCG.4 Cell permeable. Orally bioavailable