Tolcapone, CAS [[134308-13-7]]

Product Overview

• Article Name: Tolcapone, CAS [[134308-13-7]]
• Biozol Catalog Number: FBM-10-3075
• Supplier Catalog Number: 10-3075
• Alternative Catalog Number: FBM-10-3075-10MG,FBM-10-3075-50MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Ro 40-7592

Product Description

COMT inhibitor, TTR aggregation inhibitor

Product Properties

• Molecular Weight: 273.24
• Purity: 98% by TLC, NMR (Conforms)
• Form: Yellow solid
• CAS Number: [134308-13-7]
• Formula: C14H11NO5

Application Notes

• Application Notes: Catechol O-methyltransferase inhibitor (COMT), inhibiting both brain and peripheral enzymes.1 Potent inhibitor of alpha-synuclein and beta-amyloid oligomerization and fibrillogenesis protecting against extracellular toxicity.2 Binds to transthyretin (TTR) with high affinity (21 to 58 nM) and inhibits TTR aggregation in human plasma and prevents TTR-induced cytotoxicity in vitro. Stabilizes TTR in mice and humans in vivo.3 Inhibits O-methylation of exogenous polyphenols such as EGCG.4 Cell permeable. Orally bioavailable