Chemical Name: (10S,13S)-5-[(3R)-3,7-dimethylocta-1,6-dien-3-yl]-13-(hydroxymethyl)-9-methyl-10-propan-2-yl-3,9,12-triazatricyclo[6.6.1.04,15]pentadeca-1,4,6,8(15)-tetraen-11-one. Alternate Names: Lyngbyatoxin A
Non-phorbol ester PKC activator
Molekulargewicht:
437.63
Reinheit:
>95% by HPLC, NMR (Conforms)
Formulierung:
White solid/wax
CAS Nummer:
[70497-14-2]
Formel:
C27H39N3O2
Anwendungsbeschreibung:
Teleocidin A1 is a selective protein kinase C activator1 (EC50 = 40 ng/ml) representing a new class of non-phorbol ester tumor promotor2. Teleocidin A1 mimics the effect of diacylglycerol (DAG), activating PKC, but unlike DAG causes persistent activation.3 It enhances actin redistribution, vacuole formation and c-fos expression in PLC/PRF/5 hepatoma cells.4 Occurs in toxic cyanobacterial blooms.5
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