CU-CPT8m, CAS [[125079-83-6]]

Produktübersicht

• Artikelname: CU-CPT8m, CAS [[125079-83-6]]
• Artikelnummer: FBM-10-3374
• Hersteller Artikelnummer: 10-3374
• Alternativnummer: FBM-10-3374-5MG, FBM-10-3374-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 7-(3-Methylphenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxamide

Produktbeschreibung

TLR8 antagonist

Produkteigenschaften

• Reinheit: >98% by HPLC, NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [125079-83-6]
• Formel: C14H12N4O

Anwendungsbeschreibung

• Anwendungsbeschreibung: CU-CPT8m is a potent and selective antagonist of toll-like receptor 8 (TLR8) acting via stabilization of the TLR8 homodimer.1 It inhibits TNFalpha and IL-8 expression induced by the TLR8 agonist resiquimod at 1 mM and suppresses TLR8-mediated proinflammatory signaling in various cell lines, human primary cells and patient specimens. It reverses phenotypes involved in TLR8-activating fibroblasts.2 CU-CPT8m promotes erythroid cell proliferation and differentiation.3