Chemical Name: 7-(3-Methylphenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxamide
TLR8 antagonist
Purity:
>98% by HPLC, NMR (Conforms)
Form:
White solid
CAS Number:
[125079-83-6]
Formula:
C14H12N4O
Application Notes:
CU-CPT8m is a potent and selective antagonist of toll-like receptor 8 (TLR8) acting via stabilization of the TLR8 homodimer.1 It inhibits TNFalpha and IL-8 expression induced by the TLR8 agonist resiquimod at 1 mM and suppresses TLR8-mediated proinflammatory signaling in various cell lines, human primary cells and patient specimens. It reverses phenotypes involved in TLR8-activating fibroblasts.2 CU-CPT8m promotes erythroid cell proliferation and differentiation.3
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