CLP-3094, CAS [[312749-73-8]]

Produktübersicht

• Artikelname: CLP-3094, CAS [[312749-73-8]]
• Artikelnummer: FBM-10-3382
• Hersteller Artikelnummer: 10-3382
• Alternativnummer: FBM-10-3382-5MG, FBM-10-3382-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 2-{[2-(4-Chlorophenoxy)ethyl]thio}-1H-benzimidazole

Produktbeschreibung

GPR142 antagonist

Produkteigenschaften

• Molekulargewicht: 304.79
• Reinheit: 98% by TLC NMR (Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [312749-73-8]
• Formel: C15H13ClN2OS

Anwendungsbeschreibung

• Anwendungsbeschreibung: GPR142 is highly expressed in the pancreas and immune system and shares 33% homology with GPR1391. Endogenous agonists identified to date include aromatic amino acids such as tryptophan and phenylalanine2. CLP-3094 was identified as a potent and selective GPR142 antagonist with an IC50=2.3 M against 1 mM L-tryptophan. It inhibited insulin secretion from islets induced by L-tryptophan and other agonists and displayed anti-inflammatory activity in a mouse arthritis model.3