CLP-3094, CAS [[312749-73-8]]

Product Overview

• Article Name: CLP-3094, CAS [[312749-73-8]]
• Biozol Catalog Number: FBM-10-3382
• Supplier Catalog Number: 10-3382
• Alternative Catalog Number: FBM-10-3382-5MG, FBM-10-3382-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 2-{[2-(4-Chlorophenoxy)ethyl]thio}-1H-benzimidazole

Product Description

GPR142 antagonist

Product Properties

• Molecular Weight: 304.79
• Purity: 98% by TLC NMR (Conforms)
• Form: Off-white solid
• CAS Number: [312749-73-8]
• Formula: C15H13ClN2OS

Application Notes

• Application Notes: GPR142 is highly expressed in the pancreas and immune system and shares 33% homology with GPR1391. Endogenous agonists identified to date include aromatic amino acids such as tryptophan and phenylalanine2. CLP-3094 was identified as a potent and selective GPR142 antagonist with an IC50=2.3 M against 1 mM L-tryptophan. It inhibited insulin secretion from islets induced by L-tryptophan and other agonists and displayed anti-inflammatory activity in a mouse arthritis model.3