AA43279, CAS [[354812-16-1]]

Produktübersicht

• Artikelname: AA43279, CAS [[354812-16-1]]
• Artikelnummer: FBM-10-3503
• Hersteller Artikelnummer: 10-3503
• Alternativnummer: FBM-10-3503-5MG, FBM-10-3503-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 3-Amino-5-(4-methoxyphenyl)thiophene-2-carboxamide

Produktbeschreibung

Nav 1.1 activator

Produkteigenschaften

• Molekulargewicht: 248.30
• Reinheit: 97% by TLC NMR (Conforms)
• Formulierung: Tan solid
• CAS Nummer: [354812-16-1]
• Formel: C12H12N2O2S

Anwendungsbeschreibung

• Anwendungsbeschreibung: Selective Nav1.1activator. In HEK-293 cells expressing human Nav1.1 channels AA43279 increased the Nav1.1-mediated current in a concentration dependent manner (EC50=9.5 µM). In rat hippocampal brain slices it increased the firing activity parvalbumin-expressing, fast-spiking GABAergic interneurons and increased the spontaneous inhibitory post-synaptic currents recorded from pyramidal neurons. It displayed anticonvulsant activity in vivo. Important tool compound for exploring the physiology of Nav1.1 channels.1