AA43279, CAS [[354812-16-1]]

Product Overview

• Article Name: AA43279, CAS [[354812-16-1]]
• Biozol Catalog Number: FBM-10-3503
• Supplier Catalog Number: 10-3503
• Alternative Catalog Number: FBM-10-3503-5MG,FBM-10-3503-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien

Product Description

Nav 1.1 activator

Product Properties

• Molecular Weight: 248.30
• Purity: 97% by TLC NMR (Conforms)
• Form: Tan solid
• CAS Number: [354812-16-1]
• Formula: C12H12N2O2S

Application Notes

• Application Notes: Selective Nav1.1activator. In HEK-293 cells expressing human Nav1.1 channels AA43279 increased the Nav1.1-mediated current in a concentration dependent manner (EC50=9.5 µM). In rat hippocampal brain slices it increased the firing activity parvalbumin-expressing, fast-spiking GABAergic interneurons and increased the spontaneous inhibitory post-synaptic currents recorded from pyramidal neurons. It displayed anticonvulsant activity in vivo. Important tool compound for exploring the physiology of Nav1.1 channels.1