ABT-737, CAS [[852808-04-9]]

Produktübersicht

• Artikelname: ABT-737, CAS [[852808-04-9]]
• Artikelnummer: FBM-10-3661
• Hersteller Artikelnummer: 10-3661
• Alternativnummer: FBM-10-3661-5MG, FBM-10-3661-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-benzamide

Produktbeschreibung

Senolytic Bcl2 inhibitor

Produkteigenschaften

• Molekulargewicht: 813.43
• Reinheit: 98% by HPLC, NMR (Conforms)
• Formulierung: Yellow solid
• CAS Nummer: [852808-04-9]
• Formel: C42H45ClN6O5S2

Anwendungsbeschreibung

• Anwendungsbeschreibung: Inhibitor of anti-apoptotic proteins from the Bcl family: Bcl-2, Bcl-X(L), and Bcl-w (Ki < 1 nM) that causes regression of solid tumors in mice.1 Senolytic agent which disrupts aberrant p21 expression, inducing apoptosis in senescent cells, and enhancing liver regeneration in mice.2,3 Acts synergistically to reduce cell viability when combined with CDK inhibitor purvalanol A in preclinical models of acute myeloid leukemia (AML).4