ABT-737, CAS [[852808-04-9]]

Product Overview

• Article Name: ABT-737, CAS [[852808-04-9]]
• Biozol Catalog Number: FBM-10-3661
• Supplier Catalog Number: 10-3661
• Alternative Catalog Number: FBM-10-3661-5MG, FBM-10-3661-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-benzamide

Product Description

Senolytic Bcl2 inhibitor

Product Properties

• Molecular Weight: 813.43
• Purity: 98% by HPLC, NMR (Conforms)
• Form: Yellow solid
• CAS Number: [852808-04-9]
• Formula: C42H45ClN6O5S2

Application Notes

• Application Notes: Inhibitor of anti-apoptotic proteins from the Bcl family: Bcl-2, Bcl-X(L), and Bcl-w (Ki < 1 nM) that causes regression of solid tumors in mice.1 Senolytic agent which disrupts aberrant p21 expression, inducing apoptosis in senescent cells, and enhancing liver regeneration in mice.2,3 Acts synergistically to reduce cell viability when combined with CDK inhibitor purvalanol A in preclinical models of acute myeloid leukemia (AML).4