Tafamidis, CAS [[594839-88-0]]

Produktübersicht

• Artikelname: Tafamidis, CAS [[594839-88-0]]
• Artikelnummer: FBM-10-3743
• Hersteller Artikelnummer: 10-3743
• Alternativnummer: FBM-10-3743-5MG, FBM-10-3743-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 2-(3,5-Dichlorophenyl)-6-benzoxazolecarboxylic. Alternate Names: PF-06291826

Produktbeschreibung

Transthyretin stabilizer

Produkteigenschaften

• Molekulargewicht: 308.12
• Reinheit: 98% by TLC NMR (Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [594839-88-0]
• Formel: C14H7Cl2NO3

Anwendungsbeschreibung

• Anwendungsbeschreibung: A potent and selective transthyretin (TTR) kinetic stabilizer. It binds selectively and with negative cooperativity to the two normally unoccupied thyroxine binding sites of the TTR tetramer (Kd = ~2 and ~200 nM)1. Stabilizes wild-type and mutant TTR under varying conditions in vitro (EC50=2.7-3.2 M).1 Clinically useful for the treatment of familial amyloid polyneuropathy2,3 and TTR-related cardiomyopathy4.