Chemical Name: 2-(3,5-Dichlorophenyl)-6-benzoxazolecarboxylic. Alternate Names: PF-06291826
Transthyretin stabilizer
Molecular Weight:
308.12
Purity:
98% by TLC NMR (Conforms)
Form:
Off-white solid
CAS Number:
[594839-88-0]
Formula:
C14H7Cl2NO3
Application Notes:
A potent and selective transthyretin (TTR) kinetic stabilizer. It binds selectively and with negative cooperativity to the two normally unoccupied thyroxine binding sites of the TTR tetramer (Kd = ~2 and ~200 nM)1. Stabilizes wild-type and mutant TTR under varying conditions in vitro (EC50=2.7-3.2 M).1 Clinically useful for the treatment of familial amyloid polyneuropathy2,3 and TTR-related cardiomyopathy4.
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