NOTUMib-1

Produktübersicht

• Artikelname: NOTUMib-1
• Artikelnummer: FBM-10-3756
• Hersteller Artikelnummer: 10-3756
• Alternativnummer: FBM-10-3756-5MG, FBM-10-3756-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: N-(Isoquinolin-6-yl)-2-(o-tolyloxy)acetamide

Produktbeschreibung

NOTUM inhibitor, restores Wnt signaling

Produkteigenschaften

• Molekulargewicht: 292.33
• Reinheit: 98% by TLC NMR (Conforms)
• Formulierung: Beige solid
• Formel: C18H16N2O2

Anwendungsbeschreibung

• Anwendungsbeschreibung: NOTUM is a carboxylesterase which depalmitoylates Wnt proteins which results in disruption of Wnt signaling1. NOTUMib-1 inhibits the carboxylesterase activity of NOTUM, IC50=0.085 M, and restores Wnt signaling. An important new tool for use in cellular disease models in which overactivity of NOTUM suppresses Wnt activity2. NOTUM inhibitors have potential as new therapeutics for degenerative diseaes3.