NOTUMib-1

Product Overview

• Article Name: NOTUMib-1
• Biozol Catalog Number: FBM-10-3756
• Supplier Catalog Number: 10-3756
• Alternative Catalog Number: FBM-10-3756-5MG,FBM-10-3756-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien

Product Description

NOTUM inhibitor, restores Wnt signaling

Product Properties

• Molecular Weight: 292.33
• Purity: 98% by TLC NMR (Conforms)
• Form: Beige solid
• CAS Number: [Unknown]
• Formula: C18H16N2O2

Application Notes

• Application Notes: NOTUM is a carboxylesterase which depalmitoylates Wnt proteins which results in disruption of Wnt signaling1. NOTUMib-1 inhibits the carboxylesterase activity of NOTUM, IC50=0.085 M, and restores Wnt signaling. An important new tool for use in cellular disease models in which overactivity of NOTUM suppresses Wnt activity2. NOTUM inhibitors have potential as new therapeutics for degenerative diseaes3.