JNJ-63533054, CAS [[1802326-66-4]]

Produktübersicht

• Artikelname: JNJ-63533054, CAS [[1802326-66-4]]
• Artikelnummer: FBM-10-3880
• Hersteller Artikelnummer: 10-3880
• Alternativnummer: FBM-10-3880-5MG, FBM-10-3880-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: (S)-3-Chloro-N-(2-oxo-2-((1-phenylethyl)amino)ethyl) benzamide

Produktbeschreibung

GPR139 agonist, supresses morphine intake

Produkteigenschaften

• Molekulargewicht: 316.78
• Reinheit: 98% by HPLC NMr (Conforms)
• Formulierung: White solid
• CAS Nummer: [1802326-66-4]
• Formel: C17H17ClN2O2

Anwendungsbeschreibung

• Anwendungsbeschreibung: Potent and selective brain-penetrant GPR139 agonist (EC50=16 nM) an orphan G-protein-coupled receptor expressed in the CNS.1 Tritium-labeled JNJ-63533054 binds to cell membranes expressing GPR139 and can be displaced by putative endogenous ligands.2 Decreases compulsive-like alcohol drinking and hyperalgesia in alcohol-dependent rodents.3 Suppresses morphine intake in a mouse self-administration model.4