JNJ-63533054, CAS [[1802326-66-4]]

Product Overview

• Article Name: JNJ-63533054, CAS [[1802326-66-4]]
• Biozol Catalog Number: FBM-10-3880
• Supplier Catalog Number: 10-3880
• Alternative Catalog Number: FBM-10-3880-5MG,FBM-10-3880-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien

Product Description

GPR139 agonist, supresses morphine intake

Product Properties

• Molecular Weight: 316.78
• Purity: 98% by HPLC NMr (Conforms)
• Form: White solid
• CAS Number: [1802326-66-4]
• Formula: C17H17ClN2O2

Application Notes

• Application Notes: Potent and selective brain-penetrant GPR139 agonist (EC50=16 nM) an orphan G-protein-coupled receptor expressed in the CNS.1 Tritium-labeled JNJ-63533054 binds to cell membranes expressing GPR139 and can be displaced by putative endogenous ligands.2 Decreases compulsive-like alcohol drinking and hyperalgesia in alcohol-dependent rodents.3 Suppresses morphine intake in a mouse self-administration model.4