Baricitinib, CAS [[1187594-09-7]]

Produktübersicht

• Artikelname: Baricitinib, CAS [[1187594-09-7]]
• Artikelnummer: FBM-10-3893
• Hersteller Artikelnummer: 10-3893
• Alternativnummer: FBM-10-3893-5MG, FBM-10-3893-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidine-acetonitrile. Alternate Names: INCB028050, LY3009104

Produktbeschreibung

JAK 1/2 inhibitor

Produkteigenschaften

• Molekulargewicht: 371.42
• Reinheit: 98% by HPLC NMR (conforms)
• Formulierung: White or off-white solid
• CAS Nummer: [1187594-09-7]
• Formel: C16H17N7O2S

Anwendungsbeschreibung

• Anwendungsbeschreibung: Baricitinib, approved by the FDA for two inflammatory disorders, rheumatoid arthritis and alopecia areata, selectively inhibits Janus kinase 1 (IC50 = 5.9 nM) and 2 (5.7 nM), over 3 (0.56 µM).1 It thereby blocks JAK/STAT signaling, reducing cytokine release and suppressing the innate and adaptive immune systems.1,2 Was recently shown to significantly improve COVID-19 symptoms in a preliminary human trial, presumably through suppression of the cytokine release syndrome (''cytokine storm) induced by SARS-CoV-2 infection.3