Baricitinib, CAS [[1187594-09-7]]

Product Overview

• Article Name: Baricitinib, CAS [[1187594-09-7]]
• Biozol Catalog Number: FBM-10-3893
• Supplier Catalog Number: 10-3893
• Alternative Catalog Number: FBM-10-3893-5MG, FBM-10-3893-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidine-acetonitrile. Alternate Names: INCB028050, LY3009104

Product Description

JAK 1/2 inhibitor

Product Properties

• Molecular Weight: 371.42
• Purity: 98% by HPLC NMR (conforms)
• Form: White or off-white solid
• CAS Number: [1187594-09-7]
• Formula: C16H17N7O2S

Application Notes

• Application Notes: Baricitinib, approved by the FDA for two inflammatory disorders, rheumatoid arthritis and alopecia areata, selectively inhibits Janus kinase 1 (IC50 = 5.9 nM) and 2 (5.7 nM), over 3 (0.56 µM).1 It thereby blocks JAK/STAT signaling, reducing cytokine release and suppressing the innate and adaptive immune systems.1,2 Was recently shown to significantly improve COVID-19 symptoms in a preliminary human trial, presumably through suppression of the cytokine release syndrome (''cytokine storm) induced by SARS-CoV-2 infection.3