SI-2, CAS [[380537-35-9]]

Produktübersicht

• Artikelname: SI-2, CAS [[380537-35-9]]
• Artikelnummer: FBM-10-3903
• Hersteller Artikelnummer: 10-3903
• Alternativnummer: FBM-10-3903-5MG,FBM-10-3903-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

Potent inhibitor of steroid receptor coactivator-3 (SRC-3)

Produkteigenschaften

• Molekulargewicht: 265.31
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: Pale orange solid
• CAS Nummer: [380537-35-9]
• Formel: C15H15N5

Anwendungsbeschreibung

• Anwendungsbeschreibung: Si-2 is a potent inhibitor of steroid receptor coactivator-3 (SRC-3).1 It blocks MDA-MB-468 cell growth with an IC50 = 3.4 nM without effecting normal cells.1 It significantly inhibited breast cancer cell growth in an orthotopic MDA-MD-468 mouse model. Treatment of MCF-7 or triple negative MDA-MB-231 cells with SI-2 resulted in inhibition of proliferation and breast cancer stem cell (CSC) tumorsphere formation.2 CSC markers CD44+/CD24-/1o and aldehyde dehydrogenase (ALDH) were also reduced indicating that SI-2 can selectively interfere with the TIC/CSC state in breast cancer cells.2,3