SI-2, CAS [[380537-35-9]]

Product Overview

• Article Name: SI-2, CAS [[380537-35-9]]
• Biozol Catalog Number: FBM-10-3903
• Supplier Catalog Number: 10-3903
• Alternative Catalog Number: FBM-10-3903-5MG,FBM-10-3903-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien

Product Description

Potent inhibitor of steroid receptor coactivator-3 (SRC-3)

Product Properties

• Molecular Weight: 265.31
• Purity: 98% by HPLC NMR (Conforms)
• Form: Pale orange solid
• CAS Number: [380537-35-9]
• Formula: C15H15N5

Application Notes

• Application Notes: Si-2 is a potent inhibitor of steroid receptor coactivator-3 (SRC-3).1 It blocks MDA-MB-468 cell growth with an IC50 = 3.4 nM without effecting normal cells.1 It significantly inhibited breast cancer cell growth in an orthotopic MDA-MD-468 mouse model. Treatment of MCF-7 or triple negative MDA-MB-231 cells with SI-2 resulted in inhibition of proliferation and breast cancer stem cell (CSC) tumorsphere formation.2 CSC markers CD44+/CD24-/1o and aldehyde dehydrogenase (ALDH) were also reduced indicating that SI-2 can selectively interfere with the TIC/CSC state in breast cancer cells.2,3