Chemical Name: 1-(4-Chlorophenyl)-N-[2,6-dihydro-2-(4-methoxyphenyl)-5,5-dioxido-4H-thieno[3,4-c]pyrazol-3-yl]cyclopentanecarboxamide
Selective circadian clock protein CRY2 stabilizer
Molekulargewicht:
485.98
Reinheit:
98% by HPLC NMR (conforms)
Formulierung:
White solid
CAS Nummer:
[450338-32-6]
Formel:
C24H24ClN3O4S
Anwendungsbeschreibung:
TH301 is an isoform-selective stabilizer of the circadian clock protein CRY2. It dose-dependently lengthened the circadian period in Bmal1-dLuc and Per2-dLuc reporter cells. TH301 strongly enhanced rosiglitazone-dependent brown adipocyte differentiation revealing the importance of CRY-dependent regulation of energy metabolism and a possible new lead for anti-obesity therapeutics.
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten