Iberdomide, CAS [[1323403-33-3]]

Produktübersicht

• Artikelname: Iberdomide, CAS [[1323403-33-3]]
• Artikelnummer: FBM-10-3921
• Hersteller Artikelnummer: 10-3921
• Alternativnummer: FBM-10-3921-5MG, FBM-10-3921-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: (S)-3-(4-((4-(Morpholinometnyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione. Alternate Names: CC-220

Produktbeschreibung

Cereblon modulator/Molecular glue

Produkteigenschaften

• Molekulargewicht: 449.51
• Reinheit: >98% by HPLC , NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [1323403-33-3]
• Formel: C25H27N3O5

Anwendungsbeschreibung

• Anwendungsbeschreibung: Iberdomide is a modulator of the cullin ring ligase 4-cereblon E3 ubiquitin ligase complex with higher affinity (IC50 = 60 nM) than lenalidomide and pomalidomide leading to more potent degradation of Ikaros (IKZF1, EC50 = 1 nM)) and Aiolos (IKZF3, EC50 = 0.5 nM).1 It is more specific for the cereblon complex and does not degrade GSPT1 of CK1alpha. It displays antitumor and immunostimulatory activity in lenalidomide- and pomalidomide-resistant multiple myeloma cells.2 Iberdomide has also shown efficacy in treating the autoimmune disease cutaneous lupus erythematosus (CLE).3 It was also shown to act as an HIV-1 latency reversal agent in in CD4+ T-cells.4