Iberdomide, CAS [[1323403-33-3]]

Product Overview

• Article Name: Iberdomide, CAS [[1323403-33-3]]
• Biozol Catalog Number: FBM-10-3921
• Supplier Catalog Number: 10-3921
• Alternative Catalog Number: FBM-10-3921-5MG, FBM-10-3921-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: (S)-3-(4-((4-(Morpholinometnyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione. Alternate Names: CC-220

Product Description

Cereblon modulator/Molecular glue

Product Properties

• Molecular Weight: 449.51
• Purity: >98% by HPLC , NMR (Conforms)
• Form: White solid
• CAS Number: [1323403-33-3]
• Formula: C25H27N3O5

Application Notes

• Application Notes: Iberdomide is a modulator of the cullin ring ligase 4-cereblon E3 ubiquitin ligase complex with higher affinity (IC50 = 60 nM) than lenalidomide and pomalidomide leading to more potent degradation of Ikaros (IKZF1, EC50 = 1 nM)) and Aiolos (IKZF3, EC50 = 0.5 nM).1 It is more specific for the cereblon complex and does not degrade GSPT1 of CK1alpha. It displays antitumor and immunostimulatory activity in lenalidomide- and pomalidomide-resistant multiple myeloma cells.2 Iberdomide has also shown efficacy in treating the autoimmune disease cutaneous lupus erythematosus (CLE).3 It was also shown to act as an HIV-1 latency reversal agent in in CD4+ T-cells.4