SJ6986, CAS [[2765625-93-0]]

Produktübersicht

• Artikelname: SJ6986, CAS [[2765625-93-0]]
• Artikelnummer: FBM-10-3933
• Hersteller Artikelnummer: 10-3933
• Alternativnummer: FBM-10-3933-5MG,FBM-10-3933-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

GSPT1 molecular glue

Produkteigenschaften

• Molekulargewicht: 433.34
• Reinheit: 98% by HPLC , NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [2765625-93-0]
• Formel: C20H14F3N3O5

Anwendungsbeschreibung

• Anwendungsbeschreibung: SJ6986 is a potent (IC50 = 15 nM for Cereblon, EC50 = 1.5 nM for MV4-11 AML cells), selective, and orally bioavailable molecular glue degrader of the small GTPases G1 to S phase transition 1/2 (GSPT1/2).1 It displayed selectivity for GPST1/2 over 9000 other proteins including the classic cereblon substrates IKZF1 (Ikaros) and IZKF3 (Aiolos). SJ6986 displayed efficacy against acute lymphoblastic leukemia cell lines and xenografts.2