SJ6986, CAS [[2765625-93-0]]

Product Overview

• Article Name: SJ6986, CAS [[2765625-93-0]]
• Biozol Catalog Number: FBM-10-3933
• Supplier Catalog Number: 10-3933
• Alternative Catalog Number: FBM-10-3933-5MG, FBM-10-3933-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N-[2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]-2-(trifluoromethoxy)benzenesulfonamide

Product Description

GSPT1 molecular glue

Product Properties

• Molecular Weight: 433.34
• Purity: 98% by HPLC , NMR (Conforms)
• Form: White solid
• CAS Number: [2765625-93-0]
• Formula: C20H14F3N3O5

Application Notes

• Application Notes: SJ6986 is a potent (IC50 = 15 nM for Cereblon, EC50 = 1.5 nM for MV4-11 AML cells), selective, and orally bioavailable molecular glue degrader of the small GTPases G1 to S phase transition 1/2 (GSPT1/2).1 It displayed selectivity for GPST1/2 over 9000 other proteins including the classic cereblon substrates IKZF1 (Ikaros) and IZKF3 (Aiolos). SJ6986 displayed efficacy against acute lymphoblastic leukemia cell lines and xenografts.2