MAC-545496, CAS [[838810-96-1]]

Produktübersicht

• Artikelname: MAC-545496, CAS [[838810-96-1]]
• Artikelnummer: FBM-10-3951
• Hersteller Artikelnummer: 10-3951
• Alternativnummer: FBM-10-3951-5MG, FBM-10-3951-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: N-[(5-Chloropyridin-2-yl)carbamothioyl]-3-nitro-4-piperidin-1-ylbenzamide

Produktbeschreibung

GraR inhibitor

Produkteigenschaften

• Molekulargewicht: 419.88
• Reinheit: 98% by TLC NMR (Conforms)
• Formulierung: Yellow/orange solid
• CAS Nummer: [838810-96-1]
• Formel: C18H18ClN5O3S

Anwendungsbeschreibung

• Anwendungsbeschreibung: Inhibitor of glycopeptide-resistance-associated protein R (GraR, also known as ApsR). GraR and its regulatory system are important for virulence of S. aureus. MAC-545496 is able to reverse ß-lactam resistance in S. aureus in a G. Mellonella larvae model. 0.06 µg/mL MAC-545496 lowered the minimum inhibitory concentration (MIC) for oxacillin against S. aureus below the CLSI clinical breakpoint. It lowered the ß-lactam MIC from 512 to 8 µg/mL against S. aureus USA300.