MAC-545496, CAS [[838810-96-1]]

Product Overview

• Article Name: MAC-545496, CAS [[838810-96-1]]
• Biozol Catalog Number: FBM-10-3951
• Supplier Catalog Number: 10-3951
• Alternative Catalog Number: FBM-10-3951-5MG,FBM-10-3951-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien

Product Description

GraR inhibitor

Product Properties

• Molecular Weight: 419.88
• Purity: 98% by TLC NMR (Conforms)
• Form: Yellow/orange solid
• CAS Number: [838810-96-1]
• Formula: C18H18ClN5O3S

Application Notes

• Application Notes: Inhibitor of glycopeptide-resistance-associated protein R (GraR, also known as ApsR). GraR and its regulatory system are important for virulence of S. aureus. MAC-545496 is able to reverse ß-lactam resistance in S. aureus in a G. Mellonella larvae model. 0.06 µg/mL MAC-545496 lowered the minimum inhibitory concentration (MIC) for oxacillin against S. aureus below the CLSI clinical breakpoint. It lowered the ß-lactam MIC from 512 to 8 µg/mL against S. aureus USA300.