C19-9, CAS [[1477482-47-5]]

Produktübersicht

• Artikelname: C19-9, CAS [[1477482-47-5]]
• Artikelnummer: FBM-10-3977
• Hersteller Artikelnummer: 10-3977
• Alternativnummer: FBM-10-3977-5MG, FBM-10-3977-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: N-[(E)-(3-Hydroxy-4-methoxyphenyl)methylideneamino]-4,5,6,7-tetrahydro-1H-indazole-3-carboxamide. Alternate Names: (E)-N-(3-Hydroxy-4-methoxybenzylidene)-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide

Produktbeschreibung

non-RGD integrin alphavß3 receptor inhibitor

Produkteigenschaften

• Molekulargewicht: 314.35
• Reinheit: >98% by TLC NMR (Conforms)
• Formulierung: White to off-white solid
• CAS Nummer: [1477482-47-5]
• Formel: C16H18N4O3

Anwendungsbeschreibung

• Anwendungsbeschreibung: C19-9 (1477482-47-5) is a novel non-RGD inhibitor of the integrin alphavß3 receptor (KD = 102 nM). It was active against the human prostate carcinoma epithelial cell line 22RV1 (IC50 = 467 nM) and human prostate cancer organoids (IC50 = 652 nM). C19-9 was active in vivo in 22RV1 mouse xenografts and blocked growth in enzalutamide-resistant mouse CRPC xenografts.