C19-9, CAS [[1477482-47-5]]

Product Overview

• Article Name: C19-9, CAS [[1477482-47-5]]
• Biozol Catalog Number: FBM-10-3977
• Supplier Catalog Number: 10-3977
• Alternative Catalog Number: FBM-10-3977-5MG, FBM-10-3977-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N-[(E)-(3-Hydroxy-4-methoxyphenyl)methylideneamino]-4,5,6,7-tetrahydro-1H-indazole-3-carboxamide. Alternate Names: (E)-N-(3-Hydroxy-4-methoxybenzylidene)-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide

Product Description

non-RGD integrin alphavß3 receptor inhibitor

Product Properties

• Molecular Weight: 314.35
• Purity: >98% by TLC NMR (Conforms)
• Form: White to off-white solid
• CAS Number: [1477482-47-5]
• Formula: C16H18N4O3

Application Notes

• Application Notes: C19-9 (1477482-47-5) is a novel non-RGD inhibitor of the integrin alphavß3 receptor (KD = 102 nM). It was active against the human prostate carcinoma epithelial cell line 22RV1 (IC50 = 467 nM) and human prostate cancer organoids (IC50 = 652 nM). C19-9 was active in vivo in 22RV1 mouse xenografts and blocked growth in enzalutamide-resistant mouse CRPC xenografts.