Chemical Name: 1-(2-Bromophenyl)-3-[(3R)-1-[5-(trifluoromethyl)pyridine-2-yl]pyrrolidine-3-yl]urea
TRPV1 antagonist
Molekulargewicht:
429.24
Reinheit:
98% by HPLC , NMR (Conforms)
Formulierung:
White solid
CAS Nummer:
[501951-42-4]
Formel:
C17H16BrF3N4O
Anwendungsbeschreibung:
Potent and selective antagonist of the TRPV1 receptor (IC50s for receptor induction method: Capsaicin = 3 nM, Acid (pH5.3) = pIC50 7.1, and Heat = 6 nM) with activity in human, rat, and guinea pig receptors.1,2 SB-705498s activity is voltage dependent and shows >100 fold selectivity over the closely related TRPM8 receptor.2
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