ML210, CAS [[1360705-96-9]]

Produktübersicht

• Artikelname: ML210, CAS [[1360705-96-9]]
• Artikelnummer: FBM-10-4002
• Hersteller Artikelnummer: 10-4002
• Alternativnummer: FBM-10-4002-10MG, FBM-10-4002-50MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: (4-(Bis(4-chlorophenyl)methyl)piperazine-1-yl)(5-methyl-4-nitroisoxazol-3-yl)methanone

Produktbeschreibung

GPX4 inhibitor / Ferroptosis inducer

Produkteigenschaften

• Molekulargewicht: 475.32
• Reinheit: 99% by HPLC, NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [1360705-96-9]
• Formel: C22H20Cl2N4O4

Anwendungsbeschreibung

• Anwendungsbeschreibung: ML210 is selectively synthetic lethal to HRAS expressing cells compared to isogenic non-HRAS cells (IC50 = 7.1 nM for BJeLR (expressing HRASg12v) cells vs IC50 = 272 nM for BJeH-LT (non-HRAS expressing) cells.1 ML210 is able to inhibit glutathione peroxidase 4 (GPX4), an important selenoenzyme that protects cells from ferroptosis caused by iron catalyzed formation of free radicals from lipid peroxides.2,3 Treatment of several treatment-resistant cancer cell lines exhibiting a high mesenchymal state with ML210 resulted in selective induction of ferroptosis.3