ML210, CAS [[1360705-96-9]]

Product Overview

• Article Name: ML210, CAS [[1360705-96-9]]
• Biozol Catalog Number: FBM-10-4002
• Supplier Catalog Number: 10-4002
• Alternative Catalog Number: FBM-10-4002-10MG, FBM-10-4002-50MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: (4-(Bis(4-chlorophenyl)methyl)piperazine-1-yl)(5-methyl-4-nitroisoxazol-3-yl)methanone

Product Description

GPX4 inhibitor / Ferroptosis inducer

Product Properties

• Molecular Weight: 475.32
• Purity: 99% by HPLC, NMR (Conforms)
• Form: White solid
• CAS Number: [1360705-96-9]
• Formula: C22H20Cl2N4O4

Application Notes

• Application Notes: ML210 is selectively synthetic lethal to HRAS expressing cells compared to isogenic non-HRAS cells (IC50 = 7.1 nM for BJeLR (expressing HRASg12v) cells vs IC50 = 272 nM for BJeH-LT (non-HRAS expressing) cells.1 ML210 is able to inhibit glutathione peroxidase 4 (GPX4), an important selenoenzyme that protects cells from ferroptosis caused by iron catalyzed formation of free radicals from lipid peroxides.2,3 Treatment of several treatment-resistant cancer cell lines exhibiting a high mesenchymal state with ML210 resulted in selective induction of ferroptosis.3