Talabostat mesylate, CAS [[150080-09-4]]

Produktübersicht

• Artikelname: Talabostat mesylate, CAS [[150080-09-4]]
• Artikelnummer: FBM-10-4005
• Hersteller Artikelnummer: 10-4005
• Alternativnummer: FBM-10-4005-5MG,FBM-10-4005-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Val-boroPro, PT-100

Produktbeschreibung

S9 family serine protease inhibitor

Produkteigenschaften

• Molekulargewicht: 310.18
• Reinheit: 97% by HPLC, NMR (conforms)
• Formulierung: White solid
• CAS Nummer: [150080-09-4]
• Formel: C9H19BN2O3CH3SO3H

Anwendungsbeschreibung

• Anwendungsbeschreibung: Talabostat mesylate is a non-selective inhibitor of the S9 family of serine proteases (IC50s: DPPIV = <4nM, DPP8 = 4nM, DPP9 = 11nM, QPP = 310nM, FAP = 560nM, PEP = 390nM).1 Toxicity caused by DPP8/9 inhibition observed with non-selective DPPIV inhibitors limits their use as a diabetes treatment. However, Talabostat displays potent antitumor effects dependent on an intact host immune response.2 It mediates tumor regression by accelerating the expansion of tumor-specific T cells.3 Additionally, DPP8/9 inhibition by Talabostat activates the proprotein form of Caspase-1 leading to a proinflammatory form of cell death in monocytes and macrophages - pyroptosis.4 Pyroptosis induction by DPP8/9 inhibition has been shown to be caused by activation of the inflammasome sensor protein NLRP1B.5