Talabostat mesylate, CAS [[150080-09-4]]

Product Overview

• Article Name: Talabostat mesylate, CAS [[150080-09-4]]
• Biozol Catalog Number: FBM-10-4005
• Supplier Catalog Number: 10-4005
• Alternative Catalog Number: FBM-10-4005-5MG, FBM-10-4005-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: ((2R)-1-((2S)-2-Amino-3-methylbutanoyl)pyrrolidin-2-yl)boronic acid methanesulfonate. Alternate Names: Val-boroPro, PT-100

Product Description

S9 family serine protease inhibitor

Product Properties

• Molecular Weight: 310.18
• Purity: 97% by HPLC, NMR (conforms)
• Form: White solid
• CAS Number: [150080-09-4]
• Formula: C9H19BN2O3CH3SO3H

Application Notes

• Application Notes: Talabostat mesylate is a non-selective inhibitor of the S9 family of serine proteases (IC50s: DPPIV = <4nM, DPP8 = 4nM, DPP9 = 11nM, QPP = 310nM, FAP = 560nM, PEP = 390nM).1 Toxicity caused by DPP8/9 inhibition observed with non-selective DPPIV inhibitors limits their use as a diabetes treatment. However, Talabostat displays potent antitumor effects dependent on an intact host immune response.2 It mediates tumor regression by accelerating the expansion of tumor-specific T cells.3 Additionally, DPP8/9 inhibition by Talabostat activates the proprotein form of Caspase-1 leading to a proinflammatory form of cell death in monocytes and macrophages - pyroptosis.4 Pyroptosis induction by DPP8/9 inhibition has been shown to be caused by activation of the inflammasome sensor protein NLRP1B.5