Grapiprant, CAS [[415903-37-6]]

Produktübersicht

• Artikelname: Grapiprant, CAS [[415903-37-6]]
• Artikelnummer: FBM-10-4006
• Hersteller Artikelnummer: 10-4006
• Alternativnummer: FBM-10-4006-5MG, FBM-10-4006-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 1-[2-[4-(2-Ethyl-4,6-dimethylimidazo[4,5-c]pyridine-1-yl)phenyl]ethyl]-3-(4-methylphenyl)sulfonylurea. Alternate Names: CJ-023,423, ARY-007

Produktbeschreibung

EP4 receptor antagonist.

Produkteigenschaften

• Molekulargewicht: 491.61
• Reinheit: 98% by TLC NMR (Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [415903-37-6]
• Formel: C26H29N5O3S

Anwendungsbeschreibung

• Anwendungsbeschreibung: Grapiprant is a potent (Ki = 13 nM for human and 20 nM for rat) and selective prostaglandin EP4 receptor antagonist.1 It produces antihyperalgesic effects in animal models of pain, and has significant anti-inflammatory effects in a rat model of adjuvant-induced arthritis.2 EP4 receptors have been shown to be involved in PGE2 stimulation of Th1 differentiation and Th17 expansion revealing a potential role for PGE2 receptors in immunosuppression.3,4 Grapiprant/Pembrolizumab combination is in clinical trials for advanced or metastatic NSCLC adenocarcinoma.5