Grapiprant, CAS [[415903-37-6]]

Product Overview

• Article Name: Grapiprant, CAS [[415903-37-6]]
• Biozol Catalog Number: FBM-10-4006
• Supplier Catalog Number: 10-4006
• Alternative Catalog Number: FBM-10-4006-5MG, FBM-10-4006-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 1-[2-[4-(2-Ethyl-4,6-dimethylimidazo[4,5-c]pyridine-1-yl)phenyl]ethyl]-3-(4-methylphenyl)sulfonylurea. Alternate Names: CJ-023,423, ARY-007

Product Description

EP4 receptor antagonist.

Product Properties

• Molecular Weight: 491.61
• Purity: 98% by TLC NMR (Conforms)
• Form: Off-white solid
• CAS Number: [415903-37-6]
• Formula: C26H29N5O3S

Application Notes

• Application Notes: Grapiprant is a potent (Ki = 13 nM for human and 20 nM for rat) and selective prostaglandin EP4 receptor antagonist.1 It produces antihyperalgesic effects in animal models of pain, and has significant anti-inflammatory effects in a rat model of adjuvant-induced arthritis.2 EP4 receptors have been shown to be involved in PGE2 stimulation of Th1 differentiation and Th17 expansion revealing a potential role for PGE2 receptors in immunosuppression.3,4 Grapiprant/Pembrolizumab combination is in clinical trials for advanced or metastatic NSCLC adenocarcinoma.5