Selinexor, CAS [[1393477-72-9]]

Produktübersicht

• Artikelname: Selinexor, CAS [[1393477-72-9]]
• Artikelnummer: FBM-10-4011
• Hersteller Artikelnummer: 10-4011
• Alternativnummer: FBM-10-4011-5MG,FBM-10-4011-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: (Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-N-pyrazin-2-ylprop-2-enehydrazide,. Alternate Names: KPT-330

Produktbeschreibung

CRM1/XPO1 nuclear export receptor inhibitor

Produkteigenschaften

• Molekulargewicht: 443.31
• Reinheit: 98% by TLC NMR (Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [1393477-72-9]
• Formel: C17H11F6N7O

Anwendungsbeschreibung

• Anwendungsbeschreibung: Selinexor is a potent inhibitor of the nuclear export receptor, chromosome region maintenance 1 (CRM1, Exportin-1 (XPO1)). It exhibited potent growth suppression in various T-cell acute lymphoblastic leukemia (T-ALL) cells (IC50s = 34-203 nM)1 and pancreatic cancer cells (IC50 ~ 150 nM)2. Selinexor is being investigated as a possible chemotherapeutic in treating multiple types of cancer.3-8 Currently in clinical trials.

Bilder

10-4011