Selinexor, CAS [[1393477-72-9]]

Product Overview

• Article Name: Selinexor, CAS [[1393477-72-9]]
• Biozol Catalog Number: FBM-10-4011
• Supplier Catalog Number: 10-4011
• Alternative Catalog Number: FBM-10-4011-5MG, FBM-10-4011-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: (Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-N-pyrazin-2-ylprop-2-enehydrazide,. Alternate Names: KPT-330

Product Description

CRM1/XPO1 nuclear export receptor inhibitor

Product Properties

• Molecular Weight: 443.31
• Purity: 98% by TLC NMR (Conforms)
• Form: Off-white solid
• CAS Number: [1393477-72-9]
• Formula: C17H11F6N7O

Application Notes

• Application Notes: Selinexor is a potent inhibitor of the nuclear export receptor, chromosome region maintenance 1 (CRM1, Exportin-1 (XPO1)). It exhibited potent growth suppression in various T-cell acute lymphoblastic leukemia (T-ALL) cells (IC50s = 34-203 nM)1 and pancreatic cancer cells (IC50 ~ 150 nM)2. Selinexor is being investigated as a possible chemotherapeutic in treating multiple types of cancer.3-8 Currently in clinical trials.